性能参数

产品名称

Donepezil HCl

规格

10mM (in 1mL DMSO) 1g 5g

货号

GOY-Y3984

 含量

>98.00%

CAS

120011-70-3

别名

化学名

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride

分子式

C24H30ClNO3

分子量

分子量 415.95

溶解度

≥ 10.4mg/mL in H2O

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Donepezil Hydrochloride (Donepezil HCL) is a novel, potent and selective inhibitor of acetylcholinesterase (AChE), an enzyme possibly involved in cognitive dysfunction of patients suffering Alzheimer’s disease (AD), with the half maximal inhibition concentration IC50 value of 6.7 nM [1].

Donepezil HCL is a piperidine-class AChE inhibitor containing an N-benzylpiperdine and an indanone moiety, which confers it a longer and more selective action against AchE as compared to BuChE (IC50: 7.4 μM) [1].

Donepezil HCL has been approved by FDA for the treatment of AD, in which it has improved cognitive function of mild to severe moderate AD patients and exhibited excellent tolerability without hepatotoxicity [1].

Reference

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α-三联噻吩;α-Terthiophen 规格： 20mg

双去甲氧基姜黄素;DideMethoxy 规格： 20mg

桑皮苷C;Mulberroside C 规格： 20mg

桑辛素;Morusin 规格： 20mg

3,4-二甲氧基苯甲酸3,4-Dimethoxybenzoic acid,≥99%3415225G

4-氟苯甲酸4-Fluorobenzoic acid,98%456-22-425G

对羟基苯甲酸p-Hydroxybenzoic acid,≥99%99-96-725G

2-甲氧基苯甲酸2-Methoxybenzoic acid,99%579-75-950G

壬二酸Azelaic acid,98%123-99-925G

亚麻酸甲酯Methyl linolenate,≥99%301-00-8100MG