4'-bromo-Resveratrol
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产品名称:
4'-bromo-Resveratrol
产品型号:
GOY-Y3971
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
4'-bromo-Resveratrol≤50mg/ml in ethanol;50mg/ml in DMSO;100mg/ml in dimethyl formamide
4'-bromo-Resveratrol
的详细介绍
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性能参数
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产品名称
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4'-bromo-Resveratrol
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规格
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1mg 5mg 10mg
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货号
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GOY-Y3971
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含量
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>98.00%
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CAS
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1224713-90-9
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别名
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化学名
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5-[(1E)-2-(4-bromophenyl)ethenyl]-1,3-benzenediol
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分子式
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C14H11BrO2
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分子量
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分子量 291.1
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溶解度
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≤50mg/ml in ethanol;50mg/ml in DMSO;100mg/ml in dimethyl formamide
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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4'-bromo-Resveratrol is a Sirt1 and Sirt3 inhibitor.
Sirtuins are protein deacetylases regulating aging processes and many physiological functions. Resveratrol activates human Sirt1 and inhibits Sirt3, and can mimic calorie restriction effects including lifespan extension in lower organisms.
In vitro: Sirtuin modulation was studied by using 4’-bromo-resveratrol in a previous study. 4’-bromo-Resveratrol inhibited Sirt3 with much higher potency than resveratrol, and it also inhibited rather than activated Sirt1. Crystal structures of human Sirt3/peptide complexes of 4’ -bromo-resveratrol identified two binding sites. An internal site caused the potent inhibitory effect. 4’-bromo-Resveratrol interfered with NAD+ and substrate peptide binding, and it extended its bromo-phenyl group in a unrecognized site pocket. The second binding site for 4’-bromo-resveratrol was found to be located on the surface of Sirt3 and connected via two helices to peptide-binding active site loops. In Sirt1, this site appeared to comprise a residue that was essential for its activation by small molecules and 4’-bromo-resveratrol therefore constituted a candidate for the long-sought allosteric Sirt1 activator binding site [1].
In vivo: So far, there is no animal in vivo data for 4'-bromo-resveratrol.
Clinical trial: Up to now, 4'-bromo-resveratrol is still in the preclinical development stage.
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