性能参数

产品名称

Hispidulin

规格

10mg

货号

GOY-Y3955

 含量

>98.00%

CAS

1447-88-7

别名

化学名

5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one

分子式

C16H12O6

分子量

分子量 300.27

溶解度

DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml

储存条件

Desiccate at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.

Hispidulin induces cell death in a dose- and time-dependent manner in HepG2 cells. Hispidulin induces apoptosis through mitochondrial dysfunction, which is characterized by decreased Bcl-2/Bax ratio, disrupted mitochondrial membrane potential and increased release of cytochrome C and activated capase-3[2].

Hispidulin shows significant inhibitory effect on mice tumor size[2]. Hispidulin treatment effectively prevents ovariectomy-induced body weight loss and attenuates ovariectomy-induced bone loss. Hispidulin treatment also decreases trabecular spacing in ovariectomy mice[3]. Intraperitoneally administering hispidulin(10 or 50mg/ kg) to rats 30 min before intraperitoneally injecting kainic acid (15mg/kg) increases seizure latency and decreases seizure score. In addition, hispidulin substantially attenuates kainic acid-induced hippocampal neuronal cell death, and this protective effect is accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus[4].

蒜氨酸;(S)-3-(Allylsulp 规格： 20mg

桑色素;Morin 规格： 20mg

沙苑子苷;complanatuside 规格： 20mg

三十烷醇;1-Triacontanol 规格： 20mg

双去氧基姜黄素;Bisdemethoxy 规格： 20mg

薯蓣皂苷;Dioscin 规格： 20mg

Na-苯甲酰-L-精氨酰...Nα-Benzoyl-L-argininamide hydrochlori...965-03-71G

Na-对甲苯磺酰-L-精...Nα-p-Tosyl-L-arginine methyl ester hy...1784-03-81G

土槿甲酸DPseudolaric acid D (HPLC,≥98%)115028-67-65MG

γ-氨基丁酸γ-Aminobutyric acid,≥99%2079125G

γ-L-谷氨酰-α-萘...γ-L-Glutamyl-α-naphthylamide81012-91-125MG

L-肌肽L-Carnosine,99%305-84-01G