性能参数

产品名称

CPTH2 (hydrochloride)

规格

5mg 10mg

货号

GOY-Y3943

 含量

>98.00%

CAS

2108899-91-6

别名

化学名

2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone, monohydrochloride

分子式

C14H14ClN3S ? HCl

分子量

分子量 328.3

溶解度

≤5mg/ml in ethanol;16mg/ml in DMSO;5mg/ml in dimethyl formamide

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

CPTH2 is an inhibitor of HAT activity of Gcn5.

Histone acetyltransferases (HATs) has been identified to add the acetyl group on the specific lysine of histone H3 and H4 N-termini, and such signatures are able to increase the accessibility of the underlying chromatin at specific genes or over vast regions of the genome. Gcn5p is a chimeric protein made up of a number of functional domains.

In vitro: Previous study identified a novel molecule named CPTH2, which was selected based on its inhibitory effect on the growth of a gcn5Delta strain. This study indicated a specific chemical-genetic interaction between CPTH2 and HAT Gcn5p, suggesting that CPTH2 could inhibit the dependent functional network of Gcn5p. In addition, CPTH2 was found to be able to inhibit an in-vitro HAT reaction, which could be reverted by increasing concentration of histone H3 [1].

In vivo: In vivo, CPTH2 could decrease the acetylation of bulk histone H3 at the specific H3-AcK14 site [1].

Clinical trial: Up to now, CPTH2 is still in the preclinical development stage.

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