性能参数

产品名称

PF-CBP1 hydrochloride

规格

5mg 10mg 25mg 50mg 100mg 200mg 500mg

货号

GOY-Y3908

 含量

>98.00%

CAS

2070014-93-4

别名

N/A

化学名

N/A

分子式

C29H37ClN4O3

分子量

分子量 525.08

溶解度

DMSO: 100 mg/mL (190.45 mM); H2O: < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain.Target: CREBin vitro: PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors. [1]

[1]. Chekler EL, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96.

6-溴-1,1,4,4-四甲基-1,2,3,4-四氢化萘  27452-17-1  3,4-二氯苯甲酸甲酯  2905-68-2

间甲基苯乙腈  2947-60-6  2-氰基-3,5-二氟吡啶  298709-29-2

5-乙酰氨基-2-溴砒啶  29958-19-8  烯丙基丙二酸二乙酯  2049-80-1

三苯基磷  2136-75-6    21970-13-8

2-丁基氯化镁, 0.5M IN METHF  22649-70-3  2-巯基苯并恶唑  2382-96-9

N-甲基己内酰胺  2

特美汀Timentin4697-14-73.2G

D-别苏氨酸D-allo-Threonine,99%24830-94-2250MG

氨基胍盐酸盐Aminoguanidine hydrochloride,≥98%1937-19-525G

盐酸异丙肾上腺素Isoprenaline Hydrochloride,99%51-30-95G

尿黑酸Homogentisic acid,99%451-13-850MG

氟甲喹Flumequine,≥98.0%42835-25-61G