性能参数

产品名称

Ilorasertib hydrochloride

规格

1mg 5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y3905

 含量

>98.00%

CAS

1847485-91-9

别名

N/A

化学名

N/A

分子式

C25H22ClFN6O2S

分子量

分子量 525

溶解度

DMSO: 41.67 mg/mL (79.37 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1].

[1]. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.

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