性能参数

产品名称

Ruxolitinib phosphate

规格

5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y3889

 含量

>98.00%

CAS

1092939-17-7

别名

INCB018424 phosphate;INCB 018424 phosphate;INCB-018424 phosphate;Ruxolitinib

化学名

(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric acid

分子式

C17H21N6O4P

分子量

分子量 404.36

溶解度

≥ 20.2 mg/mL in DMSO, ≥ 6.92 mg/mL in EtOH with ultrasonic and warming, ≥ 8.03 mg/mL in H2O with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.

Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC50 of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system, and inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples[1].

Ruxolitinib (180 mg/kg, p.o.) reduces the tumor burden of mice inoculated with JAK2V617F-expressing cells without causing anemia or lymphopenia[1].

2-(三氟甲基)  3038-48-0  3-乙酰联苯  442678

2-乙氧基烟酸,98%  35969-54-1  4-氨基邻苯二甲酰亚胺  3676-85-5

3-苯基-1-(2-噻吩)-2-丙烯-1-酮  3988-77-0  5-氨基-2-甲基嘧啶  39889-94-6

3-甲基N-甲酰苯胺  3085-53-8  苯甲酰三氟丙酮  326-06-7

2-乙基溴代丁烷  3814-34-4  2,3-二氟甲苯  3828-49-7

  3832-73-3  2-氰基苯甲酸  3839-22-

二乙二醇丁醚2-(2-Butoxyethoxy)ethanol,≥99%112-34-5500ML

二乙二醇单乙醚Di(ethylene glycol) ethyl ether,≥99%111-90-0500ML

乙二醇二乙醚Ethylene glycol diethyl ether,98%629-14-1100ML

乙二醇二甲醚Ethylene glycol dimethyl ether,99.5%110-71-4100ML

二苯醚Diphenyl ether,≥99%101-84-85G

乙氧基苯Ethoxybenzene,99%103-73-1100ML