性能参数

产品名称

Pamiparib (BGB-290)

规格

1mg 5mg 10mg 25mg 50mg 100mg

货号

GOY-Y3885

 含量

>98.00%

CAS

1446261-44-4

别名

N/A

化学名

N/A

分子式

C16H15FN4O

分子量

分子量 298.31

溶解度

DMSO : 83.3 mg/mL (279.24 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor, with IC50 values of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. Pamiparib has oral bioavailability, potent PARP trapping, and capability to penetrate the brain, and can be used for the treatment of various cancers including the solid tumor[1][2].

Pamiparib shows potent DNA-trapping activity with an IC50 of 13 nM. In the cellular assays, Pamiparib inhibits intracellular PAR formation with an IC50 of 0.24 nM. Tumor cell lines with homologous recombination defects are profoundly sensitive to Pamiparib. Pamiparib is highly active both in vitro and in vivo in BRCA mutant tumors[3].

Pamiparib suppresses PARP activity in patient-derived glioblastoma multiforme and small-cell-lung cancer xenografts, and potentiates the effects of Temozolamide. In vivo activities of Pamiparib, and its combination activity with chemotherapies in patient biopsy derived small cell lung cancer (SCLC) xenograft models[4].

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