性能参数

产品名称

KDOAM-25 citrate

规格

5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y3876

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C21H33N5O9

分子量

分子量 499.51

溶解度

DMSO: 200 mg/mL (400.39 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

KDOAM-25 citrate is a potent and highly selective KDM5 sub-family of histone lysine demethylases inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].

[1]. Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.

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