性能参数

产品名称

ITF2357 (Givinostat)

规格

5mg 10mg 50mg 200mg 500mg 1g

货号

GOY-Y3875

 含量

>98.00%

CAS

732302-99-7

别名

ITF-2357, Givinostat (hydrochloride monohydrate)

化学名

(6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate

分子式

C24H27N3O4.HCl.H2O

分子量

分子量 475.97

溶解度

≥ 23.8 mg/mL in DMSO, ≥ 2.9 mg/mL in H2O with ultrasonic and warming

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

ITF2357, also known as givinostat, is a potent inhibitor of both class I and class II histone deacetylase (HDAC) as well as a potent inhibitor of hematopoietic colony formation by JAKEV617F-bearing progenitor cells from chronic myeloproliferative neoplasms in vitro. Previous studies has shown that ITF2357 induces apoptosis of multiple myeloma (MM) and acute myelogenous leukemia (AML) cells following induction of p21 and down-modulation of Bcl-2 and Mcl-1 proteins and inhibits the production of pro-inflammatory cytokines (such as IL-1, IL-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ) by peripheral blood mononuclear cells as well as the production of IL-6 and vascular endothelium growth factor (VEGF) by mesenchymal stromal cells.

  5349-60-0  4-苯磺酰苯甲酸  5361-54-6

紫苏醇  536-59-4  7-甲基吲哚-3-乙酸  5435-36-9

5,6-二氨基-1,3-二甲基脲嘧啶  5440-00-6  5-氯-1,3-二甲基吡唑  54454-10-3

  54610-73-0  3-溴吡唑[1,5-A]嘧啶  55405-67-9

邻氰甲基苯甲酸甲酯  1350399  3-氰甲基苯甲酸  5689-33-8

苯基氯化硒  5707-04-0  2-环己基乙醇  4442-79-9

3-氟苯甲醛3-Fluorobenzaldehyde,97%456-48-45G

2-氟苯甲醛2-Fluorobenzaldehyde,97%446-52-65G

4-氟-3-甲氧基苯甲醛4-Fluoro-3-methoxybenzaldehyde,97%128495-46-51G

2-氟-5-甲氧基苯甲醛2-Fluoro-5-methoxybenzaldehyde,97%105728-90-31G

3-羧基苯甲醛3-Formylbenzoic acid,97%619-21-61G

3-苯丙醛Hydrocinnamaldehyde,≥95%104-53-025G