性能参数

产品名称

IACS-9571 Hydrochloride (ASIS-P040 Hydrochloride)

规格

10mM*1mLinDMSO1mg 5mg 10mg 50mg 100mg

货号

GOY-Y3874

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C32H43ClN4O8S

分子量

分子量 679.22

溶解度

DMSO : 125 mg/mL (184.03 mM);H2O : 10 mg/mL (14.72 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

IACS-9571 Hydrochloride is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

IACS-9571 Hydrochloride shows excellent cellular potency with EC50 of 50 nM. IACS-9571 Hydrochloride (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 Hydrochloride is a selective dual TRIM24/BRPF1 inhibitor (Kd=1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 Hydrochloride does not interact with the BET sub-family of bromodomains, displaying greater than 7700-fold selectivity versus BRD4 (1, 2) relative to TRIM24[1].

[1]. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54.

对羟基甲基苯甲醛  52010-97-6    52024-70-1

  5397-82-0  5-[3-(三氟甲基)苯基]-2-糠酸  54022-99-0

氨基丙酸  5625-46-7  1-(3,4-二氯苯基)哌嗪  57260-67-0

2,6-二氨基庚二酸  583-93-7  2,7-二溴萘  58556-75-5

1-(2,6-二氯苯基)乙醇  53066-19-6  5-氯-2,3-二羟基吡啶  53233-89-9

D-亮氨醇  53448-09-2  邻氨基二苯胺  534-85-0

5-氯-2-氟甲苯5-Chloro-2-fluorotoluene,98%452-66-45ML

4-氯-2-氟甲苯4-Chloro-2-fluorotoluene,≥99%452-75-525G

2-氯-6-氟甲苯2-Chloro-6-fluorotoluene,97%443-83-450G

2-氯-4-氟甲苯2-Chloro-4-fluorotoluene,99%452-73-325G

5-溴-2-氟甲苯5-Bromo-2-fluorotoluene,97%51437-00-45G

4-溴-3-氟甲苯4-Bromo-3-fluorotoluene,98%452-74-41G