性能参数

产品名称

BB-Cl-Amidine hydrochloride

规格

1mg 5mg 10mg 25mg 50mg 100mg

货号

GOY-Y3853

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C26H27Cl2N5O

分子量

分子量 496.43

溶解度

DMSO: ≥ 100 mg/mL (201.44 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor. PAD[1].

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1]. Animal Model: MRL/lpr mice[1].

[1]. Knight JS, et al. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec;74(12):2199-206.

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