性能参数

产品名称

1-Naphthohydroxamic acid

规格

5mg 10mg 50mg 100mg 200mg 500mg

货号

GOY-Y3843

 含量

>98.00%

CAS

6953-61-3

别名

N/A

化学名

N/A

分子式

C11H9NO2

分子量

分子量 187.19

溶解度

DMSO: 125 mg/mL (667.77 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].

[1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. [2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9.

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