性能参数

产品名称

Rucaparib (free base)

规格

10mM (in 1mL DMSO)5mg 10mg 50mg 200mg

货号

GOY-Y3838

 含量

>98.00%

CAS

283173-50-2

别名

N/A

化学名

8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one

分子式

C19H18FN3O

分子量

分子量 323.36

溶解度

≥ 16.15mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair.

2-甲基-3H-苯并咪唑-5-羧酸  709-19-3  5,5-二甲己烷2,4-二酮  1974959

4,5-二氯-2-硝基甲苯  7494-45-3  3-甲氧基-4-叔丁基苯甲酸  79822-46-1

1-(2-甲基苯基)乙醇  7287-82-3  4-氯苯甲酸乙酯  7335-27-5

磷酸二氢钠  7558-80-7  N-苄基甘氨酸盐酸盐  7689-50-1

1,1,1,3,3,3-六氟代-2-苯基-2-丙醇  718-64-9  3-（苄氨基）丙腈  706-03-6

硫酸锰  77

4-溴-2,6-二氟苯酚4-Bromo-2,6-difluorophenol,97%104197-13-91G

4-氟-3-三氟甲基苯酚4-Fluoro-3-(trifluoromethyl)phenol,98%61721-07-11G

2-氯-5-(三氟甲基)...2-Chloro-5-(trifluoromethyl)phenol,96%40889-91-61G

3-溴-5-氟苯酚3-Bromo-5-fluorophenol,97%433939-27-61G

2-氨基-4-溴苯酚2-Amino-4-bromophenol,≥98.0%40925-68-61G

4-溴-3,5-二甲基苯酚4-Bromo-3,5-dimethylphenol,99%7463-51-65G