Bromodomain Inhibitor, (+)-JQ1
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产品名称:
Bromodomain Inhibitor, (+)-JQ1
产品型号:
GOY-Y3767
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
Bromodomain Inhibitor, (+)-JQ1≥ 22.8mg/mL in DMSO
Bromodomain Inhibitor, (+)-JQ1
的详细介绍
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性能参数
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产品名称
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Bromodomain Inhibitor, (+)-JQ1
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规格
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10mM (in 1mL DMSO)1mg 5mg 10mg 50mg
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货号
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GOY-Y3767
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含量
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>98.00%
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CAS
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1268524-70-4
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别名
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N/A
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化学名
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(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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分子式
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C23H25ClN4O2S
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分子量
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分子量 456.99
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溶解度
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≥ 22.8mg/mL in DMSO
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Bromodomain Inhibitor, (+)-JQ1 is a potent and highly specific inhibitor for the BET (bromodomain and extra-terminal) family of bromodomains. (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~ 50 and 90 nM, respectively. The binding is competitive with acetyl lysine. (+)-JQ1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
JQ1 exhibited strong dose-and time- dependent inhibition of BRDT and could significantly diminish the activity of a close structural relative of BRDT. A close look at JQ1 bound BRDT confirmed that the acetyl-lysine recognition site of BRDT was blocked. [1]
JQ1 does not produce sedative or anxiolytic effects and is instead a potent and selective inhibitor of the bromodomain testis-specific protein BRDT [2], which is essential for chromatin remodeling during spermatogenesis. By blocking BRDT, JQ1 effectively blocks the production of sperm in the testes and consequently produces effective contraception, without the negative side effects associated with previously researched hormonal contraceptives for men.
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