BI-9321 trihydrochloride
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产品名称:
BI-9321 trihydrochloride
产品型号:
GOY-Y3764
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
BI-9321 trihydrochlorideDMSO: 250 mg/mL (532.13 mM)
BI-9321 trihydrochloride
的详细介绍
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性能参数
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产品名称
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BI-9321 trihydrochloride
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规格
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5mg 10mg 25mg 50mg 100mg
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货号
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GOY-Y3764
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含量
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>98.00%
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CAS
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2387510-87-2
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别名
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N/A
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化学名
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N/A
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分子式
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C22H24Cl3FN4
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分子量
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分子量 469.81
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溶解度
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DMSO: 250 mg/mL (532.13 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells[1].
[1]. B?ttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.
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