性能参数

产品名称

Baricitinib 

规格

10mM (in 1mL DMSO)5mg 10mg 50mg 200mg

货号

GOY-Y3763

 含量

>98.00%

CAS

1187594-09-7

别名

INCB 028050,INCB-028050,LY 3009104,LY-3009104

化学名

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile

分子式

C16H17N7O2S

分子量

分子量 371.42

溶解度

≥ 18.57 mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Baricitinib, formerly named LY3009104 or INCB028050, is a new selective orally bioavailable inhibitor of tyrosine-protein kinase JAK1 or JAK2. Also, it is an ATP competitive kinase inhibitor. In vitro, it is able to inhibit JAK1 and JAK2 in a low nanomolar range with IC50 values of 5.9 and 5.7 nM, respectively, while it demonstrates low inhibitory activity for JAK3 and moderate activity for TYK2. Baricitinib inhibits intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23 at concentrations <50 nM. It should also be recognized that JAK signaling is central to a number of fundamental processes, including the generation of RBCs

R-联萘酚磷酸酯  39648-67-4  N-乙基-5-甲基-2-(1-甲基乙基)环己甲酰胺  39711-79-0

6-苯基吡啶-2-羧酸  39774-28-2  3-酮庚酸甲酯  39815-78-6

5-氟吡啶-3-甲醛  39891-04-8  (氯甲?；?乙酸乙酯  33142-21-1

2-呋喃甲酰肼  3326-71-4  4-甲基嘧啶  3438-46-8

6-氟(1H)吲唑  348-25-4  3-溴甲基噻吩  34846-44-1

二(1,5-环辛二烯)四氟硼酸铑(I)  351

2,3,4-**氧基苯甲醛2,3,4-Trimethoxybenzaldehyde,99%2103-57-310G

10-十一烯醛Undecylenic aldehyde,95%112-45-825G

2,3,4-三羟基苯甲醛2,3,4-Trihydroxybenzaldehyde,98%893365G

2,4,6-**氧基苯甲醛2,4,6-Trimethoxybenzaldehyde,98%830-79-55G

桃醛γ-Undecalactone,≥98%104-67-625ML

噻吩-2-甲醛2-Thiophenecarboxaldehyde,98%3585725G