PROTAC BET Degrader-1
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产品名称:
PROTAC BET Degrader-1
产品型号:
GOY-Y3748
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
PROTAC BET Degrader-1DMSO : ≥ 50 mg/mL (57.35 mM)
PROTAC BET Degrader-1
的详细介绍
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性能参数
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产品名称
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PROTAC BET Degrader-1
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规格
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10mM*1mLinDMSO 5mg 10mg 25mg
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货号
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GOY-Y3748
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含量
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>98.00%
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CAS
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2093386-22-0
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别名
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N/A
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化学名
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N/A
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分子式
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C44H45N11O9
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分子量
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分子量 871.9
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溶解度
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DMSO : ≥ 50 mg/mL (57.35 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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PROTAC BET Degrader-1 is a potent BET degrader based on PROTAC, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.
PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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