性能参数

产品名称

PROTAC BET degrader-2

规格

10mM*1mLinDMSO 5mg 10mg 25mg

货号

GOY-Y3747

 含量

>98.00%

CAS

2093388-33-9

别名

N/A

化学名

N/A

分子式

C41H42N10O6

分子量

分子量 770.84

溶解度

DMSO : 50 mg/mL (64.86 mM);H2O : < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

2-氨基-4-氰基嘧啶  75833-38-4  2-氯-5-甲基吡嗪  59303-10-5

2-甲基-6-三氟甲基苯胺  88301-98-8  3-溴哒嗪  88491-61-6

N-BOC-3-环己酮胺  885280-38-6  6-溴-1H-吲唑-4-甲酸  885523-08-0

2-氯嘧啶-5-羧酸乙酯  89793-12-4  7-碘吲哚  89976-15-8

3,5-二氟苄胺  90390-27-5  2-氯吩噻嗪  92-39-7

对羟基联苯  92-69-3  反式-2-己烯-1

4-氟联苯4-Fluorobiphenyl.95%324-74-31G

3-碘三氟甲苯3-Iodobenzotrifluoride,98%401-81-010G

1,4-二溴-2-氟苯1,4-Dibromo-2-fluorobenzene,98%1435-52-525G

2,4-二氟碘苯2,4-Difluoroiodobenzene,98%2265-93-25G

3,5-二氟碘苯1-Bromo-3-(difluoromethoxy)benzene,97%2265-91-01G

1-溴-3-(二氟甲氧基...1-Bromo-3-(difluoromethoxy)benzene,97%262587-05-31G