性能参数

产品名称

PJ34 hydrochloride

规格

10mM (in 1mL DMSO) 5mg 10mg 50mg

货号

GOY-Y3741

 含量

>98.00%

CAS

344458-15-7

别名

PJ 34 Hydrochloride

化学名

2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride

分子式

C17H17N3O2.HCl

分子量

分子量 331.8

溶解度

≥ 16.6 mg/mL in DMSO;H2O:50 mg/mL (150.69 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. Unlike other PARP inhibitors (such as 3-AB), PJ34 does not possess any antioxidant properties but exhibits 10,000 times greater PARP inhibition than 3-AB (EC50 = 200 μM). PJ34 has been found to have neuro-protective effects and enhance the chemotherapeutic effects in several tumor types. Study results have shown that PJ34 inhibits peroxynitrite-induced cell necrosis with EC50 value of 20 nM and dose-dependently suppresses the growth of HepG2 cells.

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