性能参数

产品名称

Olaparib (AZD2281, Ku-0059436)

规格

10mM (in 1mL DMSO) 10mg 100mg 500mg

货号

GOY-Y3736

 含量

>98.00%

CAS

763113-22-0

别名

AZD 2281,AZD-2281

化学名

4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one

分子式

C24H23FN4O3

分子量

分子量 434.46

溶解度

≥ 21.72 mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Olaparib (4-(3-4-fluorophenyl) methyl-1(2H)-one), as known as AZD2281 or KU0059436, is a novel, selective and potent inhibitor of both poly adenosine diphosphate-ribose polymeras-1 (PARP-1) and poly adenosine diphosphate-ribose polymeras-2 (PARP-2).  Having been successfully used in the treatment of tumors harboring BRCA mutations, olaparib strongly inhibits the growth of BRCA2-deficient mouse mannary tumor cell lines demonstrating cytotoxicity. In previous researches treating non-small cell lung carcinoma (NSCLC), olaparib increased the radiation sensitivity of NSCLC cells, grown as xenografts in nude mice, following radiation and increased vascular perfusion in Calu-6 tumors established in a dorsal window chamber (DWC) model.

4-苄氧基苯酚  103-16-2  4-正丁基苯胺  104-13-2

4-甲氨基苯甲酸  10541-83-0  重酸钠  10588-01-9

重酸钠  10588-01-9  5-氯-2-甲基吲哚  1075-35-0

乙酐  108-24-7  3-(三氟甲氧基)苯乙腈  108307-56-8

N,N'-亚甲基丙烯酰胺  110-26-9  硅酸乙酯  11099-06-2

硼酸  11113-50-1  草酸铵  1113-38-8

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