Histone-H2A-(107-122)-Ac-OH
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产品名称:
Histone-H2A-(107-122)-Ac-OH
产品型号:
GOY-Y3710
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
Histone-H2A-(107-122)-Ac-OH≥ 176.2mg/mL in DMSO
Histone-H2A-(107-122)-Ac-OH
的详细介绍
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性能参数
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产品名称
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Histone-H2A-(107-122)-Ac-OH
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规格
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1mg 5mg 10mg 25mg
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货号
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GOY-Y3710
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含量
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>98.00%
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CAS
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N/A
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别名
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Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH
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化学名
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N/A
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分子式
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C81H140N20O23
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分子量
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分子量 1762.1
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溶解度
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≥ 176.2mg/mL in DMSO
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Histone-H2A-(107-122)-Ac-OH, (C81H140N20O23), a peptide with the sequence Ac-Gly-Val-Leu-Pro-Asn-Ile-Gln-Ala-Val-Leu-Leu-Pro-Lys-Lys-Thr-Glu-OH, MW= 1762.1. Histone H2Ais one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histones are proteins that package DNA into nucleosomes1. Histones are responsible for maintaining the shape and structure of a nucleosome. One chromatin molecule is composed of at least one of each core histones per 100 base pairs of DNA. There are five families of histones known to date; these histones are termed H1/H5, H2A, H2B, H3, and H42.H2A is important for packaging DNA into chromatin. Since H2A packages DNA molecules into chromatin, the packaging process will effect gene expression.H2A has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin. Inadvertently, H2A has been found to regulate gene expression3. DNA modification by H2A occurs in the cell nucleus. Proteins responsible for nuclear import of H2A protein are karyopherin and importin. Recent studies also show that nucleosome assembly protein 1 is also used to transport of H2A into the nucleus so it can wrap DNA. Other functions of H2A have been seen in the histone variant H2A.Z. This variant is associated with gene activation, silencing and suppression of antisense RNA. In addition, when H2A.Z was studied in human and yeast cells, it was used to promote RNA polymerase II recruitment4.
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