性能参数

产品名称

coumarin-SAHA

规格

1mg  5mg 10mg 25mg

货号

GOY-Y3686

 含量

>98.00%

CAS

1260635-77-5

别名

coumarin-Suberoylanilide Hydroxamic Acid

化学名

N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide

分子式

C18H22N2O5

分子量

分子量 346.4

溶解度

5mg/mL in DMSO, 5mg/mL in DMF

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1]  coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC.  [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively and is quenched by 50% when bound to HDAC8. [2] This probe can be used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes and is well-suited for high-throughput screening.

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