性能参数

产品名称

Crotonoside

规格

1mg  5mg 10mg 20mg

货号

GOY-Y3682

 含量

>98.00%

CAS

1818-71-9

别名

N/A

化学名

N/A

分子式

C10H13N5O5

分子量

分子量 283.24

溶解度

DMSO: 25 mg/mL (88.26 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML[1].

Crotonoside (0-200 μM;) selectively inhibits the viability of AML cell line MV4-11, MOLM-13 (with FLT3-ITD mutant) and KG-1 (without FLT3-ITD mutant) in a dose-dependent manner with an IC50 of 11.6 μM, 12.7 μM and 17.2 μM, respectively[1].Crotonoside (0-100μM; 7 hours) inhibits the phosphorylation of FLT3 Erk1/2, Akt/mTOR and STAT5 is strongly inhibited by crotonoside at higher concentration of 12.5 μM in a concentration-dependent manner[1].Crotonoside (0-100 μM; 12 hours) exhibits a dose-dependent increase in the percentage of G0/G1 phase and a dose-dependent decrease in the percentage of G2/M and S phases cells[1]. Crotonoside (0-100 μM; 24 hours) leads to concentration-dependent changes in the number of apoptotic MV4-11 cells, results in a dose-dependent decrease in the level of pro-caspase-3 and a dose-dependent increase in the level of the cleaved caspase-3 fragments[1]. Cell Viability Assay[1] Cell Line: AML cell line MV4-11, MOLM-13 and KG-1 cells

Crotonoside(intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily) induces a significant antitumor activity and inhibited xenograft tumor progress as compared to treatment with vehicle[1]. Animal Model: NOD-SCID mice with MV4-11 cells[1]

5-异丙基-1H-吡唑-3-胺  56367-24-9  4-氯-3-硝基苯乙酮  5465-65-6

5-氯吲哚-2-羧酸乙酯  4792-67-0  5-甲基吡嗪-2-羧酸甲酯  41110-33-2

5-嘧啶甲酸乙酯  40929-50-8  3,5-二硝基苯甲腈  4110-35-4

2'-氨基-4',5'-二甲氧基苯乙酮  4101-30-8  吡唑-3,5-二羧酸二甲酯  4077-76-3

吡唑-3,5-二羧酸二甲酯  4077-76-3  4-氯嘧啶-5-甲酸乙酯  41103-17-7

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