CARM1-IN-1 hydrochloride
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产品名称:
CARM1-IN-1 hydrochloride
产品型号:
GOY-Y3673
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
CARM1-IN-1 hydrochlorideDMSO : ≥ 38 mg/mL (64.22 mM)
CARM1-IN-1 hydrochloride
的详细介绍
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性能参数
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产品名称
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CARM1-IN-1 hydrochloride
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规格
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10mM*1mLinDMSO 5mg 10mg 50mg
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货号
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GOY-Y3673
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含量
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>98.00%
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CAS
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N/A
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别名
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N/A
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化学名
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N/A
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分子式
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C26H22Br2ClNO3
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分子量
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分子量 591.72
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溶解度
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DMSO : ≥ 38 mg/mL (64.22 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1 displays high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 shows a significant dose-dependent reduction of the PSA promoter activity.
[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.
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