性能参数

产品名称

BRD4 degrader AT1

规格

5mg  10mg 25mg 50mg

货号

GOY-Y3667

 含量

>98.00%

CAS

2098836-45-2

别名

N/A

化学名

N/A

分子式

C48H58ClN9O5S3

分子量

分子量 972.68

溶解度

DMSO : 100 mg/mL (102.81 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.

BRD4 degrader AT1 is a highly selective Brd4 degrader, with a Kd of 44 nM, for Brd4BD2 in cells. BRD4 degrader AT1 also shows Kds of 38.8 nM for a mutant Brd4BD2 (QVK), 111 ± 14 nM for Brd2BD1, 94 ± 9 nM for Brd2BD2, 35 ± 3 nM for Brd3BD1, 39 ± 8 nM for Brd3BD2, 75 ± 23 nM for Brd4BD1 and 35 ± 4 nM for a Brd2BD1 mutant (KEA). BRD4 degrader AT1 (1-3 μM) causes remarkable Brd4-selective depletion and has no or little activity against Brd2 and Brd3[1].

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

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