性能参数

产品名称

Baricitinib phosphate

规格

5mg  10mg 50mg 200mg

货号

GOY-Y3658

 含量

>98.00%

CAS

1187595-84-1

别名

INCB 028050;LY 3009104;INCB028050;LY3009104;LY-3009104;INCB-028050

化学名

2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile;phosphoric acid

分子式

C16H20N7O6PS

分子量

分子量 469.41

溶解度

≥ 172.6 mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Direct and indirect inhibition of the JAKs has demonstrated rapid and sustained improvement in clinical measures of disease. Baricitinib phosphate (INCB 028050) is a selective JAK1 and JAK2 inhibitor.

In vitro: Baricitinib phosphate is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM) and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. INCB028050 inhibits intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23 at concentrations, 50 nM [1].

In vivo: Significant efficacy was achieved in the rat adjuvant arthritis model with doses of Baricitinib phosphate providing partial and/or periodic inhibition of JAK1/JAK2 and no inhibition of JAK3. Baricitinib phosphate was also effective in multiple murine models of arthritis, with no evidence of suppression of humoral immunity or adverse hematologic effects [2].

Clinical trial: Several clinical trials have been conducted to investigated the PK, efficacy and DDI of Baricitinib phosphate in healthy people as well as in participants With Rheumatoid Arthritis.

4,6-二羟基喹啉  3517-61-1  4,6-二溴喹啉  927801-13-6

4,7-二氯喹啉  1138471-54-1  4,7-二羟基喹啉  955938-89-3

4,7-二溴喹啉  700871-88-1  2-乙基烟酸  3421-76-9

2-乙酰氨基-5-氨基吡啶  29958-14-3  2-乙酰胺基-5-硝基吡啶  5093-64-1

3,4,5,6-四氯-2-氨基吡啶  51501-52-1  3,4,5-三氯吡啶-2-甲酸  1292687

3,4,5-三氯-2-三氯甲基

邻溴苯甲醚2-Bromoanisole,97%578-57-425G

正戊醚Dipentyl ether,≥98.5%693-65-225ML

甲基叔戊基醚Tert-Amyl Methyl Ether,97%994-05-85ML

间苯二甲醚m-Dimethoxy benzene,≥98%151-10-025G

15-冠醚-515-Crown-5,98%33100-27-51G

18-冠醚-618-Crown-6,≥99.0%17455-13-95G