性能参数

产品名称

Ac-QPKK(Ac)-AMC

规格

1mg  5mg 10mg 25mg

货号

GOY-Y3643

 含量

>98.00%

CAS

1387005-23-3

别名

N/A

化学名

N/A

分子式

C36H52N8O9

分子量

分子量 740.9

溶解度

DMSO: soluble,Ethanol: soluble

储存条件

-20°C

General tips

用途

仅供科研

价格

电询

详细内容

Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3.1 It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

1.Galleano, I., Schiedel, M., Jung, M., et al.A continuous, fluorogenic sirtuin 2 deacylase assay: Substrate screening and inhibitor evaluationJ. Med. Chem.59(3)1021-1031(2017)

8-甲氧基异喹啉  1723-70-2  喹啉-8-甲酸甲酯  40245-26-9

8-喹啉甲酸乙酯  25635-22-7  8-氯-1,2,3,4-四氢异喹啉  75416-50-1

8-氯-1,2,3,4-四氢异喹啉盐酸盐  61563-33-5  7-氟喹啉  396-32-7

1,2,3,4-四氢-7-甲氧基异喹啉盐酸盐  43207-78-9  7-甲氧基-1,2,3,4-四氢异喹啉 盐酸盐  1745-05-7

8-溴-7-甲氧基喹啉  36023-06-0  7-甲氧基喹啉  4964-

安息香二甲醚Benzoin dimethyl ether,99%24650-42-825G

2-甲氧基乙醇2-Methoxyethanol,99.8%109-86-4100ML

乙二醇丁醚Ethylene glycol butyl ether,≥99%111-76-2500ML

乙二醇乙醚2-Ethoxyethanol,≥99%110-80-5500ML

丁基羟基茴香醚Butylated hydroxyanisole,≥98.5%25013-16-5100G

4,4'-二氨基二苯醚4,4′-Diaminodiphenyl ether,97%101-80-425G