2-(1,8-Naphthyridin-2-yl)phenol
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产品名称:
2-(1,8-Naphthyridin-2-yl)phenol
产品型号:
GOY-Y3639
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-09
简单介绍
2-(1,8-Naphthyridin-2-yl)phenolDMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml
2-(1,8-Naphthyridin-2-yl)phenol
的详细介绍
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性能参数
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产品名称
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2-(1,8-Naphthyridin-2-yl)phenol
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规格
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5 mg 10 mg 25 mg 50 mg
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货号
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GOY-Y3639
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含量
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>98.00%
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CAS
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65182-56-1
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别名
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N/A
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化学名
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N/A
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分子式
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C14H10N2O
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分子量
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分子量 222.2
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溶解度
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DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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2-(1,8-Naphthyridin-2-yl)phenol (2-NP) is an enhancer of STAT1 activity.1 It enhances IFN-γ-induced STAT1-dependent signaling, but not IFN-γ-induced STAT3-dependent signaling or TNF-α-induced NF-κB-dependent signaling in cell-based reporter assays when used at a concentration of 45 μM. 2-NP (45 μM) increases IFN-γ-induced expression of the STAT1 target gene IRF3 and STAT1 phosphorylation in NIH3T3 cells. It increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-γ at the same concentration.
1.Lynch, R.A., Etchin, J., Battle, T.E., et al.A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cellsCancer Res.67(3)1254-1261(2007)
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