性能参数

产品名称

Metoprine

规格

10mg  50mg 100mg

货号

GOY-Y3607

 含量

>98.00%

CAS

7761-45-7

别名

N/A

化学名

N/A

分子式

C11H10Cl2N4

分子量

分子量 269.13

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT[1][2]. Metoprine is an antifolate and antitumor agent[3].

Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner[2].Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption[1]. Animal Model: Male Sprague-dawley rats (200-280g)[2]

[1]. Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7. [2]. Zhong Chen, et al. Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats. Acta Pharmacol Sin. 2002 Jan;23(1):66-70. [3]. John R Horton, et al. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. J Mol Biol. 2005 Oct 21;353(2):334-344.

3-吡啶甲醛  500-22-1  3-溴丙胺氢溴酸盐  5003-71-4

3-甲酸乙酯  5006-62-2  6-羟基烟酸  5006-66-6

曲酸  501-30-4  维生素D2  50-14-6

氢化肉桂酸  501-52-0  氯甲酸苄酯  501-53-1

3-吡啶乙酸  501-81-5  4,6-二氯-5-甲氧基嘧啶  5018-38-2

乳酸  50-21-5  环庚酮  502-42-1

三钠盐三(3-磺酰苯...TPPTS,≥95.0%63995-70-0250MG

香草酸Vanillic acid,≥97.0%121-34-625G

噻苯咪唑Thiabendazole,98%148-79-825G

3-羟基-5-甲基异恶唑Hymexazol,97%10004-44-15G

调环酸钙Prohexadione calcium,90%127277-53-65G

草甘二磷Glyphosine,≥98.0%2439-99-85G