性能参数

产品名称

LIN28 inhibitor LI71

规格

100mg  250mg 500mg

货号

GOY-Y3597

 含量

>98.00%

CAS

1357248-83-9

别名

N/A

化学名

N/A

分子式

C21H21NO3

分子量

分子量 335.4

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM. LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells[1]. IC50: 7 uM (LIN28)[1]

[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101.

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