性能参数

产品名称

iBET-BD2

规格

1mg  5mg 10mg

货号

GOY-Y3582

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C23H27FN2O4

分子量

分子量 414.5

溶解度

DMSO: soluble

储存条件

-20°C

General tips

用途

仅供科研

价格

电询

详细内容

iBET-BD2 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2).1 It inhibits BD2 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and BRDT (IC50s = 264, 98, 49, and 214 nM, respectively) and is selective for BD2 over BD1 (IC50s = 10.96, 36.31, 70.55, and >50.11 μM for BRD2, BRD3, BRD4, and BDT, respectively) in a time-resolved FRET (TR-FRET) assay. iBET-BD2 (1 μM) inhibits IFN-γ-induced protein expression of MHC class I in K562 cells. It reduces the production of anti-KLH IgM antibodies in mice immunized with keyhole limpet hemocyanin (KLH) when administered at a dose of 40 mg/kg.

1.Gilan, O., Rioja, I., Knezevic, K., et al.Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammationScience368(6489)387-394(2020)

三氟乙酸乙酯  383-63-1  3-氯-2,4-二氟硝基苯  3847-58-3

2-肟氰乙酸乙酯  3849-21-6  2,6-二氯烟酸  38496-18-3

2,6-二氟苯甲酸  385-00-2  3-氟-2-硝基苯酚  385-01-3

2-氟-6-硝基苯甲酸  385-02-4  2-氯-6-甲氧基-3-硝基吡啶  38533-61-8

2,3-二氟溴苯  38573-88-5  1,3-环戊二酮  3859-41-4

2,3,4-三氟苯胺  3862-73-5  3,4-二氟苯胺  7defau

6-溴吲哚-3-甲醛6-Bromoindole-3-carboxaldehyde,97%17826-04-91G

5-溴-2-甲氧基苯甲醛5-Bromo-2-methoxybenzaldehyde,96%25016-01-75G

4-溴-2,6-二氟苯甲醛4-Bromo-2,6-difluorobenzaldehyde,96%537013-51-71G

3-甲基-4-硝基苯甲醚3-Methyl-4-nitroanisole,97%5367-32-85G

5-硝基香兰素5-Nitrovanillin,97%6635-20-75G

吲哚-7-甲醛Indole-7-carboxaldehyde,97%1074-88-0250MG