性能参数

产品名称

EX 527 (SEN0014196)

规格

10mM (in 1mL DMSO) 10mg 25mg

货号

GOY-Y3573

 含量

>98.00%

CAS

49843-98-3

别名

EX-527,SIRT1 Inhibitor III,SEN0014196,EX527, Selisistat

化学名

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

分子式

C13H13ClN2O

分子量

分子量 248.71

溶解度

≥ 12.4 mg/mL in DMSO, ≥ 25.45 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.

Selisistat (EX-527) is an inhibitor of SIRT1 enzymatic activity (IC50, 98 nM), identified in a high-throughput screen using bacterially expressed human SIRT1. Selisistat (EX-527) inhibits SIRT1 in a concentration-dependent manner with an IC50 of 38 nM, in agreement with the activity on bacterially expressed SIRT1. Selisistat (EX-527) has much lower potency against SIRT2 (IC50, 19.6 μM) or SIRT3 (IC50, 48.7 μM) but does not inhibit class I/II HDAC activity at concentrations up to 100 μM[1]. Selisistat (EX-527) exerts an inhibitory effect on SIRT1 activity without affecting SIRT1 expression on both mRNA and protein levels[2].

Selisistat (EX-527) abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group[3].

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