性能参数

产品名称

Entacapone

规格

10mM (in 1mL DMSO) 10mg 100mg

货号

GOY-Y3571

 含量

>98.00%

CAS

130929-57-6

别名

N/A

化学名

(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

分子式

C14H15N3O5

分子量

分子量 305.29

溶解度

≥ 13.1 mg/mL in DMSO, ≥ 12.65 mg/mL in EtOH with ultrasonic

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Entacapone is a second-generation catechol-O-methyltransferase (COMT) inhibitor that potently inhibits rat liver total COMT with the half maximal inhibition concentration IC50 and inhibition constant Ki values of 20.1 nM and 10.7 nM respectively. The IC50 values of entacapone against rate liver soluble COMT (S-COMT) and rat liver membrane-bound COMT (MB-COMT) are 14.3 nM and 73.3 nM respectively [1].

Entacapone has succbe used as an adjunct to standard levodopa-dopa decarboxylase inhibitor therapy in patients with Parkinson’s disease (PD), for its abilities to increase the bioavailability of levodopa by inhibiting the generation of 3-O-methyldopa and to prolong the duration and clinical benefit of levodopa [1].

3-溴-5-甲基吡啶  3430-16-8  2-溴-3-甲基吡啶  3430-17-9

2,5-二溴-3-甲基吡啶  3430-18-0  3-氨基-5-甲基吡啶  3430-19-1

4-甲基-3-溴吡啶  3430-22-6  3,5-二溴-4-甲基吡啶  3430-23-7

3-氨基-4-甲基吡啶  3430-27-1  3-氯-4-氟苯甲醛  34328-61-5

2-甲醇  3433-37-2  S-叔丁基亚磺酰胺  343338-28-3

2-溴溴苄  3433-80-5  D-脯氨酸  3default

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