性能参数

产品名称

BPKDi

规格

1mg  5mg 10mg

货号

GOY-Y3556

 含量

>98.00%

CAS

1201673-28-0

别名

N/A

化学名

N/A

分子式

C21H28N6O

分子量

分子量 380.5

溶解度

DMSO: soluble

储存条件

-20°C

General tips

用途

仅供科研

价格

电询

详细内容

BPKDi is an inhibitor of protein kinase D (PKD; IC50s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively).1 It is selective for PKD over PKCδ and PKCε, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 μM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 μM.

1.Monovich, L., Vega, R.B., Meredith, E., et al.A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinaseFEBS Lett.584(3)631-637(2010)

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