性能参数

产品名称

Binucleine 2

规格

1mg  5mg 10mg

货号

GOY-Y3552

 含量

>98.00%

CAS

220088-42-6

别名

N/A

化学名

N/A

分子式

C13H11ClFN5

分子量

分子量 291.7

溶解度

Chloroform: Slightly Soluble,DMSO: Slightly Soluble

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.

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