性能参数

产品名称

Bisubstrate Inhibitor 78

规格

500μg  1mg 5mg

货号

GOY-Y3551

 含量

>98.00%

CAS

2368247-39-4

别名

N/A

化学名

N/A

分子式

C25H29N7O5

分子量

分子量 507.5

溶解度

Chloroform: slightly soluble,DMF: slightly soluble,DMSO: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble

储存条件

-20°C

General tips

用途

仅供科研

价格

电询

详细内容

Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50 = 1.41 μM).1 It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 μM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when used at a concentration of 100 μM.

1.Gao, Y., van Haren, M.J., Moret, E.E., et al.Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activityJ. Med. Chem.62(14)6597-6614(2019)

2,3-二氟苯甲醛  2646-91-5  N-苄氧羰基-D-丙氨酸  26607-51-2

2-氯-N,N-二甲基乙酰胺  2675-89-0  环已羧酸  26764-36-3

4-苄氧基吡啶 N-氧化物  2683-66-1  苄氧基胺盐酸盐  2687-43-6

6-溴-1-己烯  2695-47-8  聚(六亚双氰基胍-六亚甲基二胺)盐酸盐  27083-27-8

(R)-1-叔丁氧羰基-3-(氨基甲基)吡咯烷  270912-72-6  3,5-双三氟甲基苯腈  27126-93-8

[双default-locale

卡托普利Captopril (HPLC,≥98%)62571-86-21G

雄酮Androsterone,97%53-41-81G

盐酸普奈洛尔(±)-Propranolol hydrochloride,99%318-98-91G

葡萄糖基-β-环糊精6-O-α-D-Glucosyl-β-Cyclodexrin Mono,...92517-02-725G

花生酸甲酯Methyl Icosanoate,≥99%1120-28-11G

苹果多酚Apple, Malus sylvestris, ext,80%85251-63-41G