Resminostat hydrochloride
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产品名称:
Resminostat hydrochloride
产品型号:
GOY-Y3531
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-08
简单介绍
Resminostat hydrochlorideDMF: 0.5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.5 mg/ml
Resminostat hydrochloride
的详细介绍
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性能参数
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产品名称
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Resminostat hydrochloride
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规格
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mg 50mg
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货号
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GOY-Y3531
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含量
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>98.00%
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CAS
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1187075-34-8
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别名
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RAS2410 hydrochloride;4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS-2410 hydrochloride
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化学名
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(Z)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide hydrochloride
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分子式
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C16H20ClN3O4S
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分子量
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分子量 385.87
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溶解度
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DMF: 0.5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.5 mg/ml
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].
As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266. This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53. In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study [1, 2].
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