PROTAC Sirt2 Degrader-1
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产品名称:
PROTAC Sirt2 Degrader-1
产品型号:
GOY-Y3527
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-08
简单介绍
PROTAC Sirt2 Degrader-1DMSO : ≥ 100 mg/mL (117.24 mM);H2O : < 0.1 mg/mL (insoluble)
PROTAC Sirt2 Degrader-1
的详细介绍
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性能参数
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产品名称
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PROTAC Sirt2 Degrader-1
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规格
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5mg 10mg
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货号
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GOY-Y3527
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含量
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>98.00%
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CAS
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2098487-75-1
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别名
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N/A
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化学名
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N/A
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分子式
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C40H40N10O8S2
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分子量
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分子量 852.94
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溶解度
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DMSO : ≥ 100 mg/mL (117.24 mM);H2O : < 0.1 mg/mL (insoluble)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
PROTAC Sirt2 Degrader-1 (Compound 12; 10 μM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1].|| Western Blot Analysis[1]||Cell Line:|HeLa cells|Concentration:|10 μM|Incubation Time:|1-6 hours|Result:|Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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