性能参数

产品名称

L-45 (L-Moses)

规格

5mg 10mg

货号

GOY-Y3518

 含量

>98.00%

CAS

2079885-05-3

别名

N/A

化学名

N/A

分子式

C21H24N6

分子量

分子量 360.46

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

L-45 is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126±15 nM.

L-45 disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. A structure using highly homologous (64 % identity) Brd from Plasmodium falciparum, PfGCN5, of which L-45 is also a potent ligand (isothermal titration calorimetry (ITC) KD 280 nM), is successfully obtained (PDB: 5TPX). L-45 binds in the acetylated lysines (KAc) -binding pocket of PfGCN (blue ribbon and sticks) and makes H-bonds (dotted lines) through the triazole to N1436 and the first of a network of four water molecules (red spheres)[1].

苄脒盐酸盐  1670-14-0  6-吲哚甲酸  1670-82-2

6-溴吲哚-2-羧酸  16732-65-3  5-溴吲哚-2-羧酸乙酯  16732-70-0

6-甲氧基吲哚-2-羧酸  16732-73-3  (R)-3-甲酸乙酯-L-酒石酸盐  167392-57-6

灭多威  16752-77-5  L-谷氨酸-5-苄酯  1676-73-9

硝酸铈铵  16774-21-3  对苯二甲酸单甲酯  1679-64-7

5-溴-2-氯苯甲醚  16817-43-9  氢化铝锂  16853-?

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