性能参数

产品名称

I-BET 151 dihydrochloride

规格

10 mg 50 mg

货号

GOY-Y3507

 含量

>98.00%

CAS

1883545-47-8

别名

N/A

化学名

N/A

分子式

C23H21N5O3.2HCl

分子量

分子量 488.37

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro (IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes. Also enhances fibroblast reprogramming to hiPSCs at low concentration.

Dawson et al (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478 529 PMID:21964340 |Feng et al (2014) Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports 3 817 PMID:25418726 |Shao et al (2016) Reprogramming by de-bookmarking the somatic transcriptional program through targeting of BET bromodomains. Cell Rep. 16 3138 PMID:27653680

三苯基膦醋酸钯  14588-08-0  3-溴-2-甲基丙烯  1458-98-6

叔戊醇钠  14593-46-5  1,3,5-三叔丁基苯  1460-02-2

环庚甲酸  1460-16-8  三丁基氯化锡  1461-22-9

3-氨基吡啶-2-羧酸  1462-86-8  二(**基甲硅烷基)乙炔  14630-40-1

5-溴-2-氟苯甲酸  146328-85-0  (S)-(-)-叔丁基亚磺酰胺  146374-27-8

2,6-二甲氧基苯甲酸  1466-76-8  2-氯腺嘌呤核苷 ?

ABT-3845 mg 10 mg 25 mg>98.00%Cas No. 868623-40-9C25H34F3N5O2

9-Ethylguanine50mg 100mg 250mg>98.00%Cas No. 879-08-3C7H9N5O

8Br-HA5 mg 10 mg 25 mg>95.00%Cas No. N/AC15H14BrNO5

7-Methylguanosine-d3500 μg 1 mg 5 mg>99.00%Cas No. N/AC11H12D3N5O5

6,7-Dihydro-5H-quinolin-8-one500 mg 1 g 5 g>98.00%Cas No. 56826-69-8C9H9NO

5'-deoxy-5-Fluorocytidine500mg 1g 5g>98.00%Cas No. 66335-38-4C9H12FN3O4

3,6-Dimethoxy-9H-xanthen-9-one100 mg 250 mg 1 g>98.00%Cas No. 15007-07-5C15H12O4