性能参数

产品名称

Dot1L-IN-2

规格

250mg 500mg

货号

GOY-Y3490

 含量

>98.00%

CAS

1940206-71-2

别名

N/A

化学名

N/A

分子式

C27H24N8O

分子量

分子量 476.53

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively.

Dot1L-IN-2 is a potent, selective Dot1L inhibitor, with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. Dot1L-IN-2 potently inhibits H3K79 dimethylation (IC50, 16 nM), and blocks the activity of the HoxA9 promoter (IC50, 340 nM) in cellular systems. Dot1L-IN-2 also dramatically suppresses proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50, 128 nM)[1].

[1]. Chen C, et al. Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Med Chem Lett. 2016 Jun 1;7(8):735-40.

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1--BOC-3-哌嗪甲酸甲酯  129799-08-2  5-氯-2,4-二氟苯甲酸  130025-33-1

3-氯丙基异氰酸酯  13010-19-0  氧化铝  1302-74-5

N-Cbz-3-吡咯烷酮  130312-02-6  三氧化二硼  1303-86-2

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