性能参数

产品名称

Echinomycin

规格

1mg 5mg

货号

GOY-Y3489

 含量

>98.00%

CAS

512-64-1

别名

Antibiotic A 654I； NSC 13502； NSC 526417； Quinomycin A； SK 302B

化学名

N-(2-quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-(8→1)-lactone, cyclic (3→7)-thioether-L-valine

分子式

C51H64N12O12S2

分子量

分子量 1101.3

溶解度

Soluble in DMSO, Soluble in Methanol

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription.[1][2] It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element.[1][2][3] Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons.[2][4] Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.[5]

无水醋酸钠  127-09-3  二氯二茂钛  1271-19-8

丙酮酸  127-17-3  四氯乙烯  127-18-4

N,N-二甲基乙酰胺  127-19-5  4-(2-吡啶基)-苯甲醛  127406-56-8

氯胺 B  127-52-6  3-硝基苯磺酸钠  127-68-4

1-氨基-1-环丙基氰盐酸盐  127946-77-4  N-溴代丁二酰亚胺  128-08-5

N-氯代丁二酰亚胺  128-09-6  抗氧剂264  128-37-0

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