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Adenosine dialdehyde (AdOx) has been identified as an indirect methyltransferase inhibitor.
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues.
In vitro: Previous cell-based study showed that the treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) could lead to cell cycle arrest and death in different tested cell types. In addition, the e form of cell death and phenotypical outcom was found to be strikingly dependent on the concentration of AdOx. Results showed that lower AdOx concentrations could result in a G2 arrest and predominantly cause apoptosis, which was measured by biochemical and morphological criteria. In contrast, higher concentrations of AdOx led to a novel and so far undescribed form of cell death that was characterized by distinct, caspase-independent alterations of the cell shape with a marked protuberation of the nucleus, actin aggregation, cytoplasmic extensions, as well as incomplete chromatin condensation [1].
In vivo: So far, there is no animal data reported.
Clinical trial: Up to now, AdOx is still in the preclinical development stage.
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