性能参数

产品名称

2,4-Pyridinedicarboxylic Acid (hydrate)

规格

1g 5g

货号

GOY-Y3458

 含量

>98.00%

CAS

207671-42-9

别名

N/A

化学名

N/A

分子式

C7H5NO4?H2O

分子量

分子量 185.1

溶解度

DMSO: 1.4 mg/ml,PBS (pH 7.2): 0.2 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as α-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 μM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters.

1-碘代丙烷  107-08-4  双(**基硅基)氨基钠  1070-89-9

正丙胺  107-10-8  丙腈  107-12-0

氯乙腈  107-14-2  丙二酸单乙酯  1071-46-1

乙二胺  107-15-3  2-丙炔-1-醇  107-19-7

乙二醇  107-21-1  乙二醛  107-22-2

四氢噻喃-4-酮  1072-72-6  邻溴氟苯  1072-85-1

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