性能参数

产品名称

γ-Oryzanol

规格

10mM*1mLinDMSO1g

货号

GOY-Y3456

 含量

>98.00%

CAS

11042-64-1

别名

N/A

化学名

N/A

分子式

C40H58O4

分子量

分子量 602.89

溶解度

DMSO : 62.5 mg/mL (103.67 mM);H2O : < 0.1 mg/mL (insoluble)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).

γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT 3a (IC50=22.3 μM) and DNMT 3b (maximum inhibition 57%). In contrast, the inhibitory activity of Ferulic acid, a metabolite of γ-Oryzanol, is much lower than that of γ-Oryzanol. Furthermore, γ-Oryzanol acts as a partial antagonist against ERRγ, which primarily serves as a positive regulator for DNMT1 production, and consequently decreased the activity of DNMT1[1].

The brown rice-specific bioactive component γ-Oryzanol, a mixture of ferulic acid ester and several phytosterols, attenuates the preference for dietary fat via a decrease in hypothalamic endoplasmic reticulum (ER) stress. γ-Oryzanol ameliorates HFD-induced DNA hypermethylation of the promoter region of D2R in the striatum of mice. γ-Oryzanol might regulate levels of DNMTs in a striatum-specific manner. γ-Oryzanol partially decreases ERRγ activity (an approximately 40% reduction of the innate value). Oral administration of γ-Oryzanol to male mice by gavage significantly attenuates the preference for an HFD (93% of the values for vehicle-treated mice), resulting in an apparent attenuation of body weight gain[1].

4-氯苯酚  106-48-9  对甲苯胺  106-49-0

苯醌  106-51-4  1-甲基-4-醇  106-52-5

4-溴苯硫酚  106-53-6  4-氯苯硫酚  106-54-7

碳酸氢铵  1066-33-7  丁二酸二甲酯  106-65-0

**基乙炔基硅  1066-54-2  乙酰肼  1068-57-1

5-氨基-2-三氟甲基吡啶  106877-33-2  1,2-环氧丁烷  106-88-7

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