性能参数

产品名称

JAK2 Inhibitor V, Z3

规格

5mg

货号

GOY-Y3440

 含量

>98.00%

CAS

195371-52-9

别名

Z3; NSC 42834;1-Butanone, 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-

化学名

2-methyl-1-phenyl-4-(pyridin-2-yl)-2-(2-(pyridin-2-yl)ethyl)butan-1-one

分子式

C23H24N2O

分子量

分子量 344.45

溶解度

DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.

NSC 42834 (JAK2 Inhibitor V) selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. NSC 42834 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The NSC 42834-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, NSC 42834 inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation.

维生素 C  50-81-7  新铜试剂  484-11-7

1-吡咯烷基丁腈  35543-25-0  4-硝基氯苯  100-00-5

4-硝基苯胺  100-01-6  4-硝基苯酚  100-02-7

恶霉灵  10004-44-1  对甲氧基苯乙酮  100-06-1

3-氨基-5-苯基噻吩-2-甲酸甲酯  100063-22-7  对甲氧基苯甲酰氯  100-07-2

对甲氧基苯甲酸  100-09-4  对硝基溴化苄  100-11-8

Tapinarof (WBI 1001)5mg 10mg 25mg 50mg 100mg>99.50%Cas No. 79338-84-4C17H18O2

RCGD4235mg 10mg 25mg 50mg 100mg>99.50%Cas No. 108237-91-8C15H11BrN2S

***和**

(R,R)-THC10mg>98.00%Cas No. 138090-06-9C22H24O2

(R)-DPN10mg>98.00%Cas No. 524047-78-7C15H13NO2

(±)-U-50488 hydrochloride1mg>98.00%Cas No. 67197-96-0C19H26Cl2N2O.HCl