性能参数

产品名称

Sulfasalazine

规格

10mM (in 1mL DMSO) 100mg

货号

GOY-Y3419

 含量

98.64%

CAS

599-79-1

别名

N/A

化学名

(3Z)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid

分子式

C18H14N4O5S

分子量

分子量 398.39

溶解度

≥ 17.7 mg/mL in DMSO

储存条件

Store at RT

General tips

用途

仅供科研

价格

电询

详细内容

Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.

Treatment of SW620 colon cells with sulfasalazine inhibits TNFα-, LPS-, or phorbol ester-induced NFκB activation. NFκB-dependent transcription is inhibited by sulfasalazine at micro- to millimolar concentrations. TNFα-induced nuclear translocation of NFκB is prevented by sulfasalazine through inhibition of IκBα degradation[1]. Pre-incubation with 5 mM of sulfasalazine alone significantly increases basal mRNA expression of all pro-inflammatory cytokines with levels of IL-6 mRNA increased by 80-fold compared with vehicle control[2]. Once digested, sulfasalazine is cleaved into sulfapyridine and 5-aminosalicylic acid by colonic bacteria, and the latter, too, is reported to suppress NF-kappaB activity[3].

At low doses (0.25 mM), SAS is able to suppress glioma growth by over 60% compared to untreated controls[3].

异硫氰酰甲酸乙酯  16182-04-0  奎宁环-3-醇  1619-34-7

3-溴-2-氟苯甲酸  161957-56-8  2,6-二氟苯硼酸  162101-25-9

1-Boc-3-氨甲基  162167-97-7  吡唑-3-甲酸  1621-91-6

磷酸二苄酯  1623-08-1  5-氯噻吩-2-硼酸  162607-18-3

2,4-二氯苯磺酰氯  16271-33-3  依泽替米贝  163222-33-1

对乙基苯甲酰氯  16331-45-6  1,4-丁磺酸内酯  1633?

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