性能参数

产品名称

apimod tetrahydrochloride

规格

5mg

货号

GOY-Y3410

 含量

>97.00%

CAS

164301-51-3

别名

N/A

化学名

N/A

分子式

C34H56Cl4N18O2

分子量

分子量 890.74

溶解度

Soluble in DMSO

储存条件

-20°C, protect from light

General tips

用途

仅供科研

价格

电询

详细内容

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].

[1]. Nishimatsu H, et al. Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats. Hypertens Res. 2008;31(4):737‐743. [2]. Wehner S, Set al. Inhibition of p38 mitogen-activated protein kinase pathway as prophylaxis of postoperative ileus in mice. Gastroenterology. 2009;136(2):619‐629. [3]. Wang J, et al. Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol. 2016;196(12):5130‐5137.

二氧化硅  14808-60-7  L-2 4-DIAMINOBUTYRIC ACID MONOHYDRO-CHLO  1482-98-0

4-甲基吡啶-3-硼酸  148546-82-1  四正辛基溴化铵  14866-33-2

噻菌灵  148-79-8  5-氯-2-甲基苯硼酸  148839-33-2

4-（甲磺?；┍脚鹚? 149104-88-1  4-乙?；脚鹚? 149104-90-5

2-羧基苯硼酸  149105-19-1  2-巯基苯并噻唑  149-30-4

异辛酸  149-5?

Naphazoline-d4 (hydrochloride)500 μg 1 mg 5 mg>99.00%Cas No. N/AC14H10D4N2·HCl

1-Stearoyl-d35-2-hydroxy-sn-glycero-3-PC5 mg>99.00%Cas No. 327178-92-7C26H19D35NO7P

Amodiaquine-d101mg>99.00%Cas No. 1189449-70-4C20H12ClD10N3O

Imiquimod100mg>99.00%Cas No. 99011-02-6C14H16N4

Metronidazole-d41 mg>99.00%Cas No. 1261392-47-5C6H5D4N3O3

NG,NG-dimethyl-L-Arginine-d6 (hydrochloride)1mg>99.00%Cas No. 1313730-20-9C8H12D6N4O2?2HCl

(+)-β-Citronellol250mg 500mg>99.00%Cas No. 1117-61-9C10H20O