性能参数

产品名称

NAE-IN-M22

规格

5 mg 10 mg 25 mg 50 mg 100 mg

货号

GOY-Y3334

 含量

>99.00%

CAS

864420-54-2

别名

N/A

化学名

N/A

分子式

C20H24Cl2N2

分子量

分子量 363.32

溶解度

DMSO: 250 mg/mL (688.10 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nafamostat mesylate, previously known as FUT-175, is an inhibitor of serine protease that inhibits a variety of serine proteases, including trypsin and several proteases in the coagulation cascade. Although it was originally developed as an inhibitor of complements, Nafamostat mesylate has been widely used for the treatment of inflammation (such as acute pancreatitis) and disseminated intravascular coagulation (DIC). Nafamostat mesylate exhibits extremely potent inhibition against human tryptase as well as tryptase-catalyzed hydrolysis of Boc-Phe-Ser-Arg-MCA with inhibition constant Kivalue of 95.3 pM. Besides its protease-inhibiting activity, nafamostat mesylate, in a recent study, displayed its antimicrobial activity by dose-dependently inhibiting the proliferation of chlamydial in vitro.

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